Imaging Reactive Oxygen Species with L-012 Reveals Neutrophil Extracellular Trap Formation in Pancreatic Ductal Adenocarcinoma.

Notably, patients treated with HCQ showed a trend toward reduced neutrophil ROS and decreased serum levels of the NET marker (citH3), consistent with previous clinical observations ( Figure 5 c and Figure S6 ) [ 33 ].

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While we noted a trend toward reduced neutrophil-derived ROS in HCQ-treated patients compared to those receiving neoadjuvant therapy, the difference did not reach statistical significance, likely reflecting limited sample size and highlighting the need for larger clinical datasets.

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