REDD1 Affects Proliferation, Apoptosis, Migration, and Colony Formation via p-ERK and p-JNK Signaling in Lung Adenocarcinoma Cells Under Hypoxia.

A similar promotive trend was observed with HN treatment, although it did not reach statistical significance in the CCK-8 assay ( Figure 6 E).

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Moreover, the Bax/Bcl2 ratio, an indicator of apoptosis, showed a decreasing trend after hypoxia in H1299 cells, although this change was not statistically significant.

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This effect showed a trend toward reversal upon HN or ANI administration, although it did not reach statistical significance in the case of the migration assay ( Figure S4G–I ).

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