Off-Label NOACs vs. Antiplatelets in AF-Related Stroke with GFR < 15 mL/Min/1.73 m<sup>2</sup>: A Multicenter Outcome Study.

The distribution of bleeding sites showed a trend toward a difference between groups ( p = 0.06, Supplementary Table S5 )—gastrointestinal bleeding was more frequent in the NOAC group (55.3% vs. 30.0%), whereas transfusion-requiring events occurred more often in the APT group (40.0% vs. 10.5%).

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Although the site distribution differences did not reach statistical significance, the observed pattern highlights the need for careful clinical surveillance for gastrointestinal bleeding, particularly in dialysis-dependent patients receiving NOACs.

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