Prophylactic Cranial Irradiation in Small Cell Lung Cancer: Evolution of Evidence, Current Status, and Future Directions.

When these regimens were grouped by total dose (8 Gy, 24–25 Gy, 30 Gy, and 36–40 Gy), a significant trend towards lower rates of brain metastases was seen with higher doses ( p = 0.02), which supports the dose–response effect for intracranial control.

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The subgroup analysis also showed a trend toward fewer brain metastases in those patients that were treated sooner after induction therapy, but with no difference in the overall survival.

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