Untargeted Metabolomic Study for Urinary Characterization of Adult Patients with Phenylketonuria.

Int J Mol Sci · 2025 · PMC12732599 · PMID 41465241

Europe PMC DOI

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0.0620

closest p · 1.2× alpha

0.0620

boldest claim

The sentences

showed a trendp = 0.062so close (0.05 < p ≤ 0.1)

Consistent with these urinary findings, plasma leucine concentrations were significantly lower in patients with PKU compared with controls ( p < 0.001), while plasma isoleucine only showed a trend ( p = 0.062).

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did not reach statistical significanceno p-value reported

In terms of biochemical parameters, Phe levels were markedly elevated in adults with PKU compared to healthy controls ( p < 0.001), whereas Tyr levels were slightly higher in controls, though this difference did not reach statistical significance.

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