Adeno-Associated Virus-Based Gene Therapy for Lafora Disease in <i>Epm2b</i>-Deficient Mice.

A significant decrease in NF-kB levels was observed in the hippocampus 3 months after ICV injection, with a clear trend toward reduced caspase-8, pMLKL, and Lcn2 expression, the latter particularly evident in the cortex ( Figure 5 ).

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However, despite this trend, the differences did not reach statistical significance ( Figure S2B,C ).

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