Plasma NFL, GFAP, sTREM2, pTau231, and clinical severity in progressive supranuclear palsy.

In the PSP-subcortical group, sTREM2 showed a trend toward association with third ventricular enlargement ( r = − 0.46, adjusted p = 0.049, corrected p = 0.20), and GFAP exhibited a trend toward association with pallidal atrophy ( r = − 0.57, adjusted p = 0.011, corrected p = 0.122).

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The inclusion of demographic variables (age, sex, and disease duration) further increased AUC values across most biomarker combinations, although these improvements did not reach statistical significance (DeLong p > 0.05).

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