The impact of sulfadoxine-pyrimethamine resistance on the effectiveness of intermittent preventive treatment for the prevention of malaria in pregnancy in Africa: an updated systematic review and meta-analysis.

Lancet Infect Dis · 2025 · PMC12743599 · PMID 40675171

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a clear trendno p-value reported

The results demonstrate a clear trend towards reduced effectiveness of IPTp-SP in controlling malaria infections with increasing resistance to sulfadoxine–pyrimethamine.

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a marked trendno p-value reported

There was a marked trend towards lower efficacy of IPTp-SP on reducing malaria infection with increasing resistance levels.

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