Dose and duration shape the efficacy of vonoprazan versus lansoprazole for erosive esophagitis: insights from meta-regression.

In addition, meta-regression of serum gastrin elevation ( Figure 4(e) and ( f )) revealed a significant positive correlation with both treatment duration and vonoprazan dosage, where longer therapy was associated with greater gastrin elevation compared with lansoprazole (coefficient = 1.7972 per week, p < 0.0001) and higher vonoprazan doses showed a significant trend toward increased gastrin levels (coefficient = 9.3422 per mg, p = 0.0093).

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However, in the corresponding subgroup analysis, the 40 mg regimen did not reach statistical significance because of the small sample size and wide CI.

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