Comparative Efficacy of High-Dose Daptomycin Monotherapy versus Combination Therapy for Daptomycin-Resistant <i>Enterococcus faecium</i> Endocarditis in a Rat Model.

This was significantly lower than the bacterial load in the D90F group (5.62 log 1 0 CFU/g; p = 0.02) and showed a trend towards superiority over the D90C group (5.87 log 1 0 CFU/g; p = 0.05).

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The primary finding of this study was that high-dose daptomycin monotherapy (125 mg/kg, simulating a human dose >12 mg/kg) was the most effective regimen for reducing bacterial load in a cardiac vegetation, demonstrating significantly greater bactericidal activity than combination therapy with daptomycin plus fosfomycin, and a strong trend towards superiority over daptomycin plus ceftaroline.

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