Clinical efficacy at 72 hours was defined as the presence of ≥2 of the following four criteria, adapted from previous studies [ 11 ]: (i) Resolution of fever (body temperature ≤37.5°C), (ii) Normalization or clear improvement toward normalization of leukocyte count and CRP levels (Regarding leukocyte count and CRP levels: Cases in which a clear trend toward normal values was confirmed through multiple blood tests were included), (iii) Documentation in the medical record indicating a clear clinical improvement as assessed by the attending physician, and (iv) A blood culture specimen drawn within 72 hours after the diagnosis that subsequently became negative.
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Prognostic Factors and Optimal Empiric Therapy for Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacterales Bacteremia.
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Although not statistically significant (p = 0.051), there was a numerical trend toward higher 30-day mortality in patients who received inappropriate initial antimicrobial therapy (OR, 7.22, 95%CI 0.74-107.88) (Table 5 ).
In subgroup analysis of patients with a qSOFA score ≥2, inappropriate empiric therapy tended to be associated with higher 30-day mortality (OR, 7.22; 95%CI, 0.74-107.88), though this did not reach statistical significance.