Neuromodulation in Parkinson's disease with transcranial pulse stimulation: evidence of clinical efficacy and cortical oscillatory changes.

A linear mixed-effects model confirmed a significant trend of improvement (slope = − 0.80 per three sessions, 95% CI: − 1.18 to − 0.41, p < 0.001), corresponding to a predicted 6.38-point reduction by follow-up.

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The parietal region exhibited the largest numerical decrease in asymmetry (baseline: 0.030; session 12: − 0.008; mean change = − 0.022), but this difference also did not reach statistical significance ( t = − 1.30, p = 0.216).

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