Synergetic effect of a DSP4-induced locus coeruleus lesion and systemic LPS exacerbates substantia nigra dopaminergic neuron loss.

Sci Rep · 2025 · PMC12749801 · PMID 41444418

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hedged sentences

0.0001

closest p · 0.0× alpha

0.0791

boldest claim

The sentences

highly significantp < 0.0001actually significant

At 3 months the Kruskal–Wallis test indicated a highly significant difference among treatment groups (Kruskal–Wallis H 3 = 23.42; 4 groups, n = 32, p < 0.0001).

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did not reach statistical significancep > 0.05actually significant

Other comparisons did not reach statistical significance ( p > 0.05) (Fig. 4 c).

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approached significancep = 0.0791so close (0.05 < p ≤ 0.1)

Although the comparison between LPS and DSP4-LPS at 6 months approached significance ( p = 0.0791), no pairwise comparisons were significant ( p > 0.05) (Fig. 6 c, d).

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