The relationship between cognitive impairment and acoustic features in major depressive disorder: a longitudinal cohort study.

BMC Psychiatry · 2025 · PMC12751515 · PMID 41261424

Europe PMC DOI

hedged sentences

0.0710

closest p · 1.4× alpha

0.0730

boldest claim

The sentences

near-significantp = 0.071so close (0.05 < p ≤ 0.1)

5 b) demonstrated the strongest PC1 effect ( β = −5.270, p < 0.001), with a near-significant PC1-time interaction (β = 1.741, p = 0.071) and the highest model fit (R2 = 0.531).

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did not reach statistical significanceP = 0.073so close (0.05 < p ≤ 0.1)

DS (median T = 48.0), CPT (median T = 49.0, d = − 0.15), and SC(median T = 48.0, d = − 0.25) did not reach statistical significance (FDR-corrected P = 0.073, 0.078, and 0.083, respectively), though trends toward impaired working memory, sustained attention, and reduced processing speed were observed.

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failed to reach significanceno p-value reported

Incorporating depressive symptoms (HAMD-17) as a covariate marginally improved model fits (|ΔAIC| = 0.4–0.8) but failed to reach significance thresholds (|ΔAIC| < 2).

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