Identification of serum proteins associated with response of triple-negative breast cancer to neoadjuvant chemotherapy: preliminary results from the INSTIGO trial.

The difference in the pre/post-NACT CX3CL1 concentration change between the groups was statistically highly significant (mean + 613 pg/mL in pCR group vs. mean − 168 pg/mL in non-pCR group), with mean difference of + 781 pg/mL (95% CI: 292 to 1271; p = 0.003) (Fig. 3 B).

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The difference between the groups, in the pre/post-NACT PD-L1 concentration change per individual patient showed a significant trend (mean − 10 pg/mL in the pCR group vs. 0 pg/mL in the non-pCR group), with a mean difference of + 10 pg/mL between the two groups (95% CI: −1.4 to 21; p = 0.08).

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Indeed, the difference in pre/post-NACT variation between the two groups did not reach statistical significance; there was a tendency of difference between the two groups with mean difference of 127 pg/mL (95% CI: −55 to 308; p = 0.2) (Fig. 4 B).

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