Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Dynamics as a Complementary Marker of Treatment Response in Newly Diagnosed Multiple Myeloma: A Prospective Analysis.

Cureus · 2025 · PMC12754562 · PMID 41479490

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did not reach statistical significanceno p-value reported

Consistent with these patterns, baseline MOTS-c values were numerically higher in responders (44.88 ± 35.05 ng/mL) compared with refractory patients (32.16 ± 14.91 ng/mL), although this difference did not reach statistical significance.

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near-significantno p-value reported

Exploratory subgroup analyses highlighted a near-significant association between MOTS-c levels and immunoglobulin subtypes, although this was not statistically confirmed in patients with IgG-secreting disease.

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did not achieve significanceno p-value reported

Notably, in the refractory group, strong correlations (r > 0.9) between MOTS-c changes and IgG variations were observed, though they did not achieve significance, likely due to limited sample size (Table 2 ).

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