Potential Survival Benefit of Adjuvant Chemotherapy in Stage IV Intrahepatic Cholangiocarcinoma: A Multicenter, Stage-Stratified Analysis.

Ann Gastroenterol Surg · 2026 · PMC12757147 · PMID 41488852

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did not reach statistical significanceno p-value reported

Among prospective trials, the BILCAP study demonstrated a survival benefit of adjuvant capecitabine over observation in patients with biliary tract cancer (BTC) in the per‐protocol analysis, although the primary intention‐to‐treat analysis did not reach statistical significance [ 6 ].

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showed a trendno p-value reported

Lymph node metastasis showed a trend toward worse survival but did not reach statistical significance (HR 1.704, 95% CI 0.976–2.975, p = 0.061).

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