Elevated blood levels of liver-expressed antimicrobial peptide 2 in patients with insulinoma and its expression in insulinomas.

Front Endocrinol (Lausanne) · 2025 · PMC12757234 · PMID 41488138

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0.0670

closest p · 1.3× alpha

0.0670

boldest claim

The sentences

did not reach statistical significanceP = 0.067so close (0.05 < p ≤ 0.1)

In controls, serum LEAP2 levels were significantly associated with BMI (P = 0.047), whereas in patients, the correlation did not reach statistical significance (P = 0.067).

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showed a trendno p-value reported

Patients with a larger tumor burden—defined as a primary tumor size ≥ 2.5 cm, the presence of multiple pancreatic tumors, or tumor metastases—showed a trend toward higher serum LEAP2 levels compared with those with a lower tumor burden (median 30.9 ng/mL, range 2.02-79.1 ng/mL vs . 20.2 ng/mL, range 14.28-70.66 ng/mL; P = 0.118; Supplementary Figure 6 ).

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