Drug-Coated Balloons Versus Other Percutaneous Coronary Intervention Strategies in De Novo Coronary Artery Disease: A Systematic Review, Meta-Analysis With Trial Sequential Analysis.

Cardiovasc Ther · 2026 · PMC12757438 · PMID 41487964

Europe PMC DOI

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

Although Asian studies showed a trend toward greater improvement in imaging outcomes, this difference did not reach statistical significance when formally tested for interaction ( p for interaction = 0.9201 for MACE and 0.0581 for LLL), suggesting that the overall treatment effect of DCB was largely consistent across populations despite baseline risk factor disparities.

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borderline significanceno p-value reported

DCBs demonstrated comparable MACE incidence to DES and a numerically lower risk compared with noncoated devices, with the interaction between comparator type and treatment effect reaching borderline significance ( p for interaction = 0.0513).

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