Molecular subtypes of hepatocellular carcinoma linked to liver cell lineages and clinical outcomes of combination immunotherapy.

A similar trend was also observed between PFS and HCC subtypes although these analyses did not reach statistical significance ( Figure 3 C).

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It is worth mentioning that, in the sorafenib control arm of IMbrave150 study, the progenitor subtype showed a trend of poor prognosis with shorter PFS and OS compared to the other subtypes ( Figure S5 ).

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