Barely Significant
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Real-world outcomes of first-line immunotherapy and subsequent systemic therapies in pleural mesothelioma: a multicenter study in China.

Transl Lung Cancer Res · 2025 · PMC12775688 · PMID 41510382

2
hedged sentences
0.0800
closest p · 1.6× alpha
0.0800
boldest claim

The sentences

did not reach statistical significanceP=0.08so close (0.05 < p ≤ 0.1)
chemotherapy did not reach statistical significance (HR, 0.43; 95% CI: 0.17–1.11; P=0.08).

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showed a trendno p-value reported
chemotherapy ± targeted therapy (weighted HR, 0.47; 95% CI: 0.23–0.95) and showed a trend toward longer PFS (weighted HR, 0.64; 95% CI: 0.34–1.17).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.