Endocrine immune-related adverse events in advanced lung cancer patients receiving immune checkpoint inhibitors: incidence, predictors and outcomes.

Transl Lung Cancer Res · 2025 · PMC12775698 · PMID 41510398

Europe PMC DOI

hedged sentences

0.2400

closest p · 4.8× alpha

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boldest claim

The sentences

a favorable trendP=0.24not close (p > 0.1)

Time-dependent cox analysis indicated that e-irAE was associated with a favorable trend in both PFS [hazard ratio (HR), 0.77; 95% CI, 0.50–1.19; P=0.24] and OS (HR, 0.84; 95% CI, 0.52–1.36; P=0.48).

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showed a trendno p-value reported

In addition, first-line ICI showed a trend toward improved OS, but was not statistically significant (HR, 0.84; 95% CI, 0.63–1.13, P=0.24).

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did not reach statistical significanceno p-value reported

The occurrence of e-irAE showed a favorable trend for both PFS (HR, 0.77; 95% CI, 0.50–1.19; P=0.24) and OS (HR, 0.84; 95% CI 0.52–1.36; P=0.48), indicating that patients who developed e-irAEs tended to have better clinical outcomes, although the associations did not reach statistical significance.

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