The Effects of Hesperidin on the Healing Process of Cleft Lip Surgical Wounds in Rats: A Histological Evaluation and Therapeutic Analysis.

Overall, as the dosage of hesperidin increased from 25 to 100 mg/kg, there was a clear trend of reduced fibroblast proliferation, shifting from marked to moderate and finally to mild.

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While incremental increases in hesperidin dosage were associated with reductions in fibroblast proliferation, collagen deposition, and inflammatory cell infiltration, these changes did not reach statistical significance at doses below 100 mg/kg.

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