Comparative efficacy of neoadjuvant imatinib therapy in gastric versus rectal gastrointestinal stromal tumors: a two-center retrospective cohort study.

Kaplan-Meier survival analysis demonstrated a trend toward better RFS in the rectal group compared to the gastric group, although the difference did not reach statistical significance (Log-rank test: χ2 = 3.633, p = 0.057; Fig. 3 A).

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84.3%, P = 0.295), and no statistically significant differences were observed for specific AEs at the any-grade or grade ≥ 3 level (all P > 0.05), although rectal GIST showed a nonsignificant trend toward more grade ≥ 3 AEs overall (19.6% vs. 9.6%, P = 0.100).

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Similarly, the pathological response showed a trend toward a higher high-response rate in the rectal group compared to the gastric group (49.0% vs. 32.5%), but without reaching statistical significance ( P = 0.057).

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