Epstein-Barr virus infection shapes the genetic, transcriptomic, and immune microenvironment landscape of Burkitt lymphoma.

However, mutational signature analysis demonstrated distinct patterns: EBV-positive tumors exhibited a higher proportion of age-related signatures, while EBV-negative tumors showed enrichment of UV-associated signatures, though these differences did not reach statistical significance ( p = 0.17 for Age; p = 0.11 for Ultraviolet) (Fig. 2 C).

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Although no statistically significant difference in survival was observed between the groups, the FOXO1 -mutated group showed a trend towards poorer survival (Fig. 1 G).

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