Spontaneous cSCC Murine Model Shows Limited Response to PD-1 Blockade and Radiation Combination Therapy.

Cancers (Basel) · 2025 · PMC12784684 · PMID 41514652

Europe PMC DOI

hedged sentences

0.3671

closest p · 7.3× alpha

0.3671

boldest claim

The sentences

did not reach statistical significancep = 0.3671not close (p > 0.1)

By day 18 (injection 9), there was a large difference in average percentage change, with the anti-PD1 group exhibiting a 24% ± 21% increase from initial tumor size, and IgG-treated tumors showing an increase of 126% ± 37% from initial tumor size, though this difference did not reach statistical significance ( p = 0.3671, Bonferroni-corrected).

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showed a trendno p-value reported

Anti-PD1 therapy showed a trend toward a slowed progression of cSCC and increased CD8+ expression in preliminary single-specimen analysis.

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