Barely Significant
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Interplay Between 3D Chromatin Architecture and Gene Regulation at the <i>APOE</i> Locus Contributes to Alzheimer's Disease Risk.

Int J Mol Sci · 2025 · PMC12785688 · PMID 41516176

Europe PMCDOI
2
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closest p · 1.0× alpha
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The sentences

did not reach statistical significancep > 0.05actually significant
Although APOC1 mRNA levels showed a genotype-associated trend, differences did not reach statistical significance ( p > 0.05).

also in 111,027 other papers

approached significanceno p-value reported
Mediation analyses further showed minimal causal effects of DNAm on CI strength or APOC1 expression, whereas direct effects approached significance, indicating that disease status and genotype impact chromatin architecture largely independent of methylation.

also in 8,237 other papers

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