Influence of APOE4 Genotypes on Nutrient-Cognition Relationship in Taiwanese Older Adults: Longitudinal Findings from the HALST.

Nutrients · 2025 · PMC12788161 · PMID 41515222

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did not reach statistical significanceno p-value reported

Among APOE4 carriers, higher TC2 scores were associated with poorer cognitive performance, whereas the non-E4 group (APOE2/3) showed an opposite directional trend, although the slope did not reach statistical significance.

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showed a trendno p-value reported

The primary findings revealed that positive associations were observed only among APOE4 carriers: individuals with higher TC1 scores exhibited a slower rate of cognitive decline, whereas those with higher TC2 scores showed a trend toward accelerated decline.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.