Barely Significant
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Nephrotoxicity secondary to CDK 4/6 inhibitors in advanced breast cancer patients and its impact on survival.

Ther Adv Med Oncol · 2026 · PMC12789390 · PMID 41523909

Europe PMCDOI
2
hedged sentences
0.1880
closest p · 3.8× alpha
0.1880
boldest claim

The sentences

showed a trendp = 0.188not close (p > 0.1)
Paradoxically, patients who developed nephrotoxicity showed a trend toward better survival outcomes: median PFS was 30 months versus 20 months ( p = 0.188), and the 3-year OS rate was 77.9% versus 63.8% ( p = 0.801), though these differences were not statistically significant.

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a positive trendno p-value reported
did not reach statistical significanceno p-value reported
In patients who developed nephrotoxicity, there was an approximately 3-fold risk reduction in the risk of death, which did not reach statistical significance but showed a positive trend.

also in 11,005 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.