Upgrade to malignancy after excision of MRI-only B3 breast lesions: should the size and histological type of the lesion be considered for therapeutic management?

Insights Imaging · 2026 · PMC12796027 · PMID 41526590

Europe PMC DOI

hedged sentences

0.4700

closest p · 9.4× alpha

0.4700

boldest claim

The sentences

did not reach statistical significancep = 0.47not close (p > 0.1)

By histological subtype, the upgrade rate was 20% in pure ADH (3/15) and lobular neoplasia (1/5), 18.2% in mixed (FEA + ADH) lesions (2/11), and only 3.7% in pure FEA lesions (1/27), although these differences did not reach statistical significance ( p = 0.47).

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a marked trendno p-value reported

Moreover, the small sample, which did not even contain all types of B3 lesions, made it difficult to obtain statistically significant results, especially in the analysis of histological types of B3 lesions, where we observed a marked trend toward upgrade in ADH lesions.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.