Downregulation of hepatic sulfotransferase 1E1 expression associated with decreased expression of multidrug resistance-associated protein 2.

4 A) and showed a trend toward decreased Sult1e1 mRNA expression in rat primary hepatocytes, although this change was not statistically significant ( Fig. 4 B).

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66 , 67 , 68 , 69 The mRNA expression levels of SULT1E1 were decreased by CDCA treatment in HepG2 cells and showed a decreasing trend in rat primary hepatocytes ( Fig. 4 ).

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Regarding AhR, CAR, and LXR, an increasing trend in the expression of 4–5 of the 10 target genes was observed.

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Treatment with OCA, an FXR agonist, showed a similar trend toward suppression of SULT1E1 promoter activity, although the change did not reach statistical significance ( Fig. 6 A).

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