Efficacy of immediate-release versus extended-release metformin on glycemic control and insulin resistance in Saudi patients with type 2 diabetes: A prospective cohort study.

These represent relative reductions of approximately 30 % (IR) and 34.8 % (XR) from baseline, each highly significant (Wilcoxon, p < 0.001 within groups) ( Table 6 , Table 7 ).

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Another way to view this is that 63 % of XR patients achieved the ADA-recommended HbA1c target of <7.0 % by 6 months compared to 50 % of IR patients; however, this difference in goal attainment did not reach statistical significance ( Figure 1 ).

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FSI and HOMA-IR did not differ significantly between sexes, but males showed a trend toward greater insulin resistance (HOMA-IR mean 2.11 in males vs. 1.83 in females).

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