From kidney injury to cardiac dysfunction: the central role of oxidative stress in diabetes and CKD.

Basic Res Cardiol · 2026 · PMC12804299 · PMID 41419687

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

failed to reach statistical significancep = 0.08so close (0.05 < p ≤ 0.1)

1 a–f), although the increase in NGAL and UPCR in DM-CKD vs DM alone failed to reach statistical significance (both p = 0.08).

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failed to reach significanceno p-value reported

However, pressure–volume (PV) loop and ultrasound measurements revealed alterations in cardiac function that were directionally similar for DM and DM_CKD, although specific alterations sometimes failed to reach significance in either group.

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showed a trendno p-value reported

The DM group showed a trend towards increased fibrosis, whereas the DM_CKD group exhibited significantly greater fibrosis than WT controls, as shown by PR staining (Fig. 9 ).

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