Micrometastasis-derived models enable drug testing for early-stage, high-risk melanoma patients.

Despite a high LN donor variation in the IL-2 control, a clear trend was visible that coculture with Mel-DCC-11 in the presence of the isotype control failed to induce CD8+ T-cell activation and proliferation, as indicated by the unchanged frequency of CD25 + and PD-1 + CD8 T cells, along with a reduced frequency of Ki-67 + and Tim3 + CD8 + T cells (Fig. 5E ).

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However, due to variation in the effect between individual donors, the changes did not reach statistical significance.

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