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Growth factor supplementation modulates survival, morphology, and network activity of neurogenin-2 induced human neurons.

Sci Rep · 2025 · PMC12808180 · PMID 41390345

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showed a trendno p-value reported
GNDF alone, or the addition of NT3 in the BDNF/GDNF combination (B/G/NT3) also maintained survival comparable to multiple GFs, but showed a trend towards decline over time (Fig. 1 B, not statistically significant).

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In contrast, cultures without GFs or treated with only a single GF displayed a higher percentage of silent neurons, although this difference did not reach statistical significance when compared to B/G/C conditions (Fig. 3 B, C).

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