Alterations in lipid, redox, and energy metabolism in recent onset psychosis: a metabolomics study in non-smoking individuals and matched controls.

G3P elevation, together with a near-significant DHAP reduction, indicates disruption of this pathway.

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Metabolites with VIP values greater than 2 included palmitic acid, stearic acid, pyruvic acid, stachyose, the cysteine/cystine pair, and taurine, many of which also showed large fold changes and highly significant p-values.

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The glycine, serine and threonine metabolism, pantothenate and CoA biosynthesis and one carbon pool by folate pathway were significantly altered in the full sample, but did not reach statistical significance in the SSD subgroup. 4 Discussion In the current study, we investigated plasma metabolites in non-smoking individuals with recent onset psychotic disorders compared to non-smoking healthy controls.

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