Machine learning and network pharmacology identify keloid biomarkers (AMPH, TNFRSF9) and therapeutic targets (IL6, HAS2) for aloe-derived quercetin.

PLoS One · 2026 · PMC12810848 · PMID 41544047

Europe PMC DOI

hedged sentences

0.1000

closest p · 2.0× alpha

0.4800

boldest claim

The sentences

did not reach statistical significanceP = 0.1so close (0.05 < p ≤ 0.1)

In our study, AMPH did not reach statistical significance in validation (P = 0.1), which may reflect the small cohort size or residual batch effects.

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failed to reach statistical significanceP = 0.48not close (p > 0.1)

Quantitative analysis of target gene expression in the independent validation cohort confirmed significant upregulation of both HAS2 (P = 0.0091) and IL6 (P = 0.036), while TOP2A failed to reach statistical significance (P = 0.48) ( Fig 9 ).

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