Differential roles of Rad18 in repressing carcinogen- and oncogene-driven mutagenesis <i>in vivo</i>.

However, the difference in γH2AX staining between genotypes did not reach statistical significance.

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Immunostaining experiments showed a trend of elevated γH2AX levels in Rad18 −/− tumors when compared with Rad18 +/+ tumors and the adjacent tongue tissue from Rad18 −/− mice (Fig. 2C ).

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