Vaginal chlorhexidine gluconate versus fluconazole for recurrent vulvovaginal candidiasis: A randomized noninferiority trial.

Although the differences between groups did not reach statistical significance in favor of FLZ, it is important to consider that the outcomes might have differed if the full cohort of planned participants had been included.

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Concerns have been raised for increasing resistance to FLZ [ 31 , 32 ], although current global data do not indicate a clear trend of rising prevalence.

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