Distinct Molecular and Prognostic Profiles of Left- and Right-Sided Colorectal Cancer Revealed by NGS Analysis: The Role of SMAD4 and SETD2 Mutations.

Cancer Med · 2026 · PMC12820718 · PMID 41562159

Europe PMC DOI

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closest p · 1.0× alpha

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boldest claim

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did not reach statistical significancep > 0.05actually significant

Although MSI‐H was observed to be mutually exclusive with TP53 , this association did not reach statistical significance ( p > 0.05).

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showed a trendno p-value reported

In both subgroups, SMAD4 mutations consistently showed a trend toward poorer OS, though not reaching statistical significance (LCC: HR = 3.67, 95% CI 0.82–16.49, p = 0.069; RCC: HR = 5.88, 95% CI 0.53–65.03, p = 0.101, Table S3 ).

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