Efficacy and safety of deferiprone for thalassemia: a systematic review and meta-analysis of randomized controlled trials.

Syst Rev · 2025 · PMC12821977 · PMID 41402903

Europe PMC DOI

hedged sentences

0.0515

closest p · 1.0× alpha

0.0515

boldest claim

The sentences

borderline significantP = 0.0515so close (0.05 < p ≤ 0.1)

(2007b) yielded a borderline significant effect favoring DFP (SMD: −0.21; 95% CI: −0.42 to 0.00; P = 0.0515), suggesting that this particular study may have influenced the overall result.

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a favorable trendno p-value reported

A favorable trend was also noted in UIE and RVEF, although these outcomes did not reach statistical significance.

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a positive trendno p-value reported

Additionally, a positive trend was observed in UIE and RVEF, though the effect estimates did not reach statistical significance.

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borderline significanceno p-value reported

In contrast, the evidence for UIE, cardiac T2* MRI, RVEF, and all-cause mortality was rated as low, primarily due to imprecision, limited number of included studies, and borderline significance in effect estimates.

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did not reach statistical significanceno p-value reported

While some trends were observed (e.g., reduced heterogeneity in adult-only groups), these did not reach statistical significance.

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near-significantno p-value reported

The pooled SMD was 0.48 (95% CI: −0.04 to 0.99; P = 0.0537; I 2 = 0%), showing a near-significant improvement with DFP (Fig. 4 D).

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