Single-cell analysis indicating CCR8 modulates CD8<sup>+</sup> tissue-resident memory T cells to attenuates rejection in transplantation.

B cells ( P = 0.0956) showed a trend toward increase, but this did not reach statistical significance, and NK cells ( P = 0.6498) did not exhibit significant changes; in peripheral blood, the proportion of T cells ( P = 0.0001) was significantly lower, with no significant changes in NK cells ( P = 0.5558) or macrophages ( P = 0.9476), while B cells ( P = 0.0873) showed a trend toward decrease and DCs ( P = 0.1177) a trend toward increase, but neither reached statistical significance (Fig.

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B cells ( P = 0.0125) showed a trend towards elevation but without statistical significance, and no significant changes were observed in DCs ( P = 0.7008) or macrophages ( P = 0.9513).

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CD69+CD103− CD8+ T cells ( P = 0.085) also showed a decreasing trend, but this was not statistically significant in the anti-CCL8 group.

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