Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults.

However, in contrast to glycine and serine, its increase in the SH120 group reached statistical significance compared to placebo after three months and a similar trend was observed in the SH60 group approaching significance threshold ( p = 0.087).

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An increasing trend in facial redness areas was noted in the placebo group over the study period on both the cheek (Fig. 2 o) and the forehead (Figure S3 ), as illustrated by representative images of the cheek in Fig. 5 .

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Enhanced skin barrier function may also be associated with the observed ability of orally administered SH to prevent the increase in facial redness that was seen in the placebo group, although this trend did not reach statistical significance.

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