Peak strain dispersion as a nonlinear mediator in HFpEF: Unraveling subtype-specific pathways via SHAP-augmented ensemble modeling.

PLoS Comput Biol · 2026 · PMC12829950 · PMID 41533691

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did not reach statistical significanceno p-value reported

In Cluster 0, eGFR showed a trend toward mediating its effects on GWW through PSD (indirect effect = 0.313), though this effect did not reach statistical significance.

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showed a trendno p-value reported

Nonlinear mediation analysis demonstrated striking subtype-specific differences in mediation patterns.In Cluster 0, eGFR showed a trend toward mediating its effects on GWW through PSD (indirect effect = 0.313), reflecting complex cardiorenal interactions in younger patients with severe renal disease.

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