A cell-state axis underlying colonization in carcinomas with implications for metastasis risk prediction and interception.

Cell Rep · 2025 · PMC12831586 · PMID 41401069

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0.1100

closest p · 2.2× alpha

0.2700

boldest claim

The sentences

did not reach statistical significancep = 0.11not close (p > 0.1)

This depletion was significant for shFos #1 (one-sided Wilcoxon signed-rank test, p = 0.04) and exhibited a strong trend for shFos #2 that did not reach statistical significance ( p = 0.11), likely due to the modest degree of knockdown (30%) with this shRNA.

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a strong trendp = 0.27not close (p > 0.1)

Importantly, this trend was observed in metastases, significantly for PACA-US (ρ = 0.42, p = 9.0E–4; Figure 6C ) and exhibiting a strong trend for PACA-CA (ρ = 0.29, p = 0.27), likely due to the limited number of metastases ( n = 16) in this cohort versus PACA-US ( n = 61).

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