Melatonin supplementation reduces delirium incidence in critically ill patients: a systematic review and meta-analysis.

Front Pharmacol · 2026 · PMC12832284 · PMID 41602948

Europe PMC DOI

hedged sentence

0.0900

closest p · 1.8× alpha

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boldest claim

The sentences

showed a trendP = 0.09so close (0.05 < p ≤ 0.1)

did not reach statistical significanceno p-value reported

Regarding length of ICU stay, pooled analysis of 12 studies showed a trend toward reduction in the melatonin group compared with controls (MD -0.45 days, 95% CI -1.10 to 0.20, P = 0.09, I 2 = 68%, Figure 7B ), although this did not reach statistical significance.

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