Efficacy and safety of opioid-receptor antagonists for opioid-induced constipation: a systematic review and meta-analysis.

Front Pharmacol · 2025 · PMC12832312 · PMID 41601989

Europe PMC DOI

hedged sentences

0.0750

closest p · 1.5× alpha

0.0750

boldest claim

The sentences

did not reach statistical significanceP = 0.075so close (0.05 < p ≤ 0.1)

The group receiving naldemedine exhibited moderate heterogeneity but did not reach statistical significance (P = 0.075, I 2 = 56.6%).

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a clear trendno p-value reported

For the incidence of OAE, a clear trend of increasing incidence was observed in the larger subgroup studies at 4 and 12 weeks.

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