Efficacy of whole-brain radiotherapy with or without simultaneous integrated boost in non-small cell lung cancer with brain metastases: a retrospective analysis.

Front Med (Lausanne) · 2025 · PMC12832967 · PMID 41601802

Europe PMC DOI

hedged sentences

0.0660

closest p · 1.3× alpha

0.0860

boldest claim

The sentences

did not reach statistical significancep = 0.066so close (0.05 < p ≤ 0.1)

Subgroup analysis revealed that patients with fewer than eight BMs who received WBRT-SIB achieved significantly longer local PFS compared with those treated with WBRT ( p = 0.043), along with a trend toward improved iPFS that did not reach statistical significance ( p = 0.066).

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showed a trendp = 0.086so close (0.05 < p ≤ 0.1)

Furthermore, anti-angiogenic therapy showed a trend as a protective factor for local PFS without reaching statistical significance ( p = 0.086).

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