Soluble Epoxide Hydrolase Inhibition Improves Alzheimer's Disease Hallmarks: Correlation with Peripheral Inflammation and Gut Microbiota Modulation.

Aging Dis · 2025 · PMC12834399 · PMID 40423637

Europe PMC DOI

hedged sentences

0.0730

closest p · 1.5× alpha

0.0760

boldest claim

The sentences

did not reach statistical significanceP = 0.073so close (0.05 < p ≤ 0.1)

At the same time, treatment with UB-BJ-02 demonstrated a trend toward mitigating the reduction in Il-6 expression, although this effect did not reach statistical significance (P = 0.073).

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showed a trendP = 0.076so close (0.05 < p ≤ 0.1)

Notably, the UB-BJ-02 treatment showed a trend towards increasing the expression of Il-10 (P = 0.076), suggesting a potential anti-inflammatory effect of this treatment.

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