Prognostic and predictive impact of NOTCH1 mutations in patients with chronic lymphocytic leukemia: a tertiary single-center experience.

Front Oncol · 2025 · PMC12834786 · PMID 41607535

Europe PMC DOI

hedged sentences

0.0750

closest p · 1.5× alpha

0.0750

boldest claim

The sentences

showed a trendp=0.075so close (0.05 < p ≤ 0.1)

Among patients with complete NOTCH1 and IGHV data (n=225), NOTCH1 m showed a trend toward worse survival in IGHV-mutated patients (HR=3.26, 95% CI: 0.89–11.94, p=0.075) but not in IGHV-unmutated patients (HR=1.29, 95% CI: 0.63–2.65, p=0.49).

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a numerical trendno p-value reported

Although stratified analysis showed a numerical trend toward a stronger NOTCH1 m effect in IGHV-mutated patients (HR=3.26 vs. 1.29), the wide confidence intervals and lack of statistical significance preclude definitive conclusions, especially given the low prevalence of NOTCH1 m in this subgroup (n=9 with 3 events).

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did not reach statistical significanceno p-value reported

The NOTCH1 m /IGHV-mutated group showed a trend toward worse survival (HR=3.41, p=0.06), although this did not reach statistical significance, likely due to the small sample size (n=9).

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